Sodium Hyaluronate
(Hyaluronic Acid)for pharmaceutical use
Kewpie is a Japanese manufacturer of pharmaceutical grade Sodium hyaluronate used as API and pharmaceutical excipients.
Our Sodium hyaluronate can be used for injections, eye drops and external preparations and others.
As a No.1 market share Sodium hyaluronate manufacturer in Japan, we can meet your tailor made derivatives needs.
Products Selection
Our products in powder form are available for injectable grade.
HYALURONSAN HA-AML, HYALURONSAN HA-SHL
| Product name | Average molecular weight (kDa range) |
Certificates and registrations | Intrinsic viscosity (m3/kg) |
Source | Image |
|---|---|---|---|---|---|
| HYALURONSAN HA-AML |
500~1,200 | GMP CEP DMF : Japan, USA, China and Korea |
1.00~1.95 | Biofermentation |  |
| HYALURONSAN HA-SHL |
1,500~3,900 | GMP CEP DMF : Japan, USA and China |
2.50~5.50 | Biofermentation |  |
HA-SHL is suitable for crosslinked Hyaluronic acid
HYALURONSAN HA-AM, HYALURONSAN HA-QSE
| Product name | Average Molecular weight (kDa range) |
Certificates and registrations | Intrinsic viscosity (m3/kg) |
Source | Image |
|---|---|---|---|---|---|
| HYALURONSAN HA-AM |
600~1,200 | GMP DMF : Japan, USA, China and Korea |
1.18~1.95 | Chicken comb |  |
| HYALURONSAN HA-QSE |
1,900~3,900 | GMP DMF : Japan and Korea |
3.00~5.50 | Chicken comb |  |
HA-QSE has a much higher molecular weight than biofermentation origin Sodium hyaluronate.
Application
| Knee injection |  |
| Submucosal injectable composition |  |
| Eye drop |  |
| Resorbable adhesion barrier |  |
| Ophthalmic viscosurgical devices |  |
| Wound healing agent |  |
| Dermal fillers |  |
| 【Others】 micro needle, drug delivery system, injectable gel, etc. |
 |
We export Sodium hyaluronate to more than 30 countries worldwide.
Contact us online
Technical Service
Molecular weight from 800Da to 3,500,000Da
We can cater to your specific needs by our specific technique for adjusting the molecular weight.
We not only have products of biofermentation origin, but we also have products of natural origin using our advanced extraction and refining technology.
Tailor-made Sodium Hyaluronate derivatives
By binding other functional compounds, Sodium hyaluronate can acquire a new function and are able to change the physical characteristics.
Our dedicated R&D team can provide Sodium hyaluronate derivatives according to your needs.
Japanese manufacturing
Long history
Kewpie has been in the food industry with a history of more than 100 years.
Kewpie has continued to be a pioneer manufacturer of Sodium hyaluronate since 1983.
In 1983 we developed our first Sodium hyaluronate from Chicken comb.
Since our company also manufactures vinegar, we utilized the fermentation technology of vinegar used for our famous mayonnaise.
By using this fermentation technology we have switched our manufacturing process to biofermentation of Lactobacillus. Since 2016 we have developed and manufactured medical devices using our Sodium hyaluronate in Japan.
Academic research
Kewpie has collaborated on research with many universities.
For example, our research has been about effects regarding knee joint pain and the mechanism of reducing wrinkles through oral intake of Hyaluronic acid.
We have published many studies regarding research results conducted in various journals.
We are also looking for partners to develop new drugs using Sodium hyaluronate in the pharmaceutical use.
High Quality and Guaranteed Safety
Made in Japan means Japanese Quality
Sodium hyaluronate (Hyaluronic acid) for pharmaceutical grade is made at our factory near Tokyo under strict regulation and quality control.
Extremely high purity
With our manufacturing knowledge we can minimize impurities. What are the benefits of high purity?
- ・Stable manufacturing.
It is easy to adjust the pH and viscosity levels in the manufacturing process of the drug due to the homeostasis between batches of the drug substance (always constant quality). - ・Stable quality of the drug.
- ・Maintenance of safety and effect of the final drug.
Kewpie's Sodium hyaluronate (Hyaluronic acid) minimizes the effect of impurities on the efficacy and safety of the final drug.
What is Hyaluronic acid?
Structure
Hyaluronic acid is a linear polysaccharide, and the structure is consisting of repetitive disaccharide units of D-glucuronic acid and N-acetyl-D-glucosamine bound by β(1→3) and β(1→4) glycosidic bonds.
Features
Hyaluronic acid has the physical properties of high viscosity, outstanding moisture keeping ability, lubricating effect etc., and physiological functions of wound healing, protection against infection, collagen fiber biosynthesis etc.
Hyaluronic acid has high solubility.
Hyaluronic acid is known to be degraded by heat, enzymes, etc., but can be stabilized by crosslinked structure.
Where is Hyaluronic Acid in your body?
Eye vitreous body
Skin
Approximately 50% of the total HA resides in the skin.
Synovial joint fluid
Hyaluronic Acid rich body parts
Always by your side
Customer friendly Sodium Hyaluronate
We can provide the best solution for your specific application.
We have Sodium hyaluronate with a wide range of molecular weights and are able to develop tailor made derivatives.
Timely expert technical support
We promote development for your product with our technical support by R&D experts and regulatory support.
We are always by your side
