Functional
Hyaluronic Acid
for various benefits
(Cosmetic Use)
Kewpie continues to strive for research and
development using
Hyaluronic acid to
improve skin problems.
What is Functional Hyaluronic Acid ?
Our Functional Hyaluronic acids are not just ordinary humectants.
In addition to high water retention and moisturization which general Hyaluronic acid has, we add new functions through our unique technologies.
Our Functional Hyaluronic acids as an ingredient are scientifically proven with strong evidence to cater to your specific needs and use.
By blending our Functional Hyaluronic acids, it will lead you to healthy and vibrant skin.
Introduction Video
Functional Hyaluronic Acid
HAbooster™"Promotes collagen cycle" Sodium hyaluronate
Very low molecular weight sodium hyaluronate promotes the collagen cycle and improves crow’s feet and nasolabial folds.Details >
Hyalorepair®“Barrier Function Recovery” Hyaluronic acid
Low molecular weight Hyaluronic acid which has been alkylated so that Hyarorepair® can have a barrier function recovery with both hydrophobic and hydrophilic aspects for skin care.Details >
Hyalo-Oligo®“Penetrative” Hyaluronic acid
Low molecular weight Hyaluronic acid not only covers the surface of the skin, but also penetrates and stays in the stratum corneum.Details >
Hyaloveil®-P"Adhesive" Hyaluronic acid
Relatively high molecular weight Sodium hyaluronate which has been cationized so that Hyaloveil®-P has an adhesive and coating effect for skin and hair.Details >
HAbooster™"Promotes collagen cycle" Sodium hyaluronate
- ・HAbooster™ is a Hyaluronic acid developed with the concept of promoting the collagen metabolism cycle which contributes to natural and beautiful skin.
- ・HAbooster™ is a very low molecular weight Sodium hyaluronate with an average of 2,000 Da.
- ・It penetrates to the upper layer of the epidermis of the skin and promotes on collagen metabolism to improve wrinkles and sagging.
Product information
INCI NAME | Hydrolyzed Sodium Hyaluronate |
---|---|
IECIC2021 | 水解透明质酸钠 |
Function | Moisturizer/Anti-wrinkle/ Elasticity |
Recommended dosage |
0.1%~ |
Appearance | Powder |
Average molecular weight |
About 2,000 Da |
ISO16128 | Natural Index:0 Derived Natural Index:1 |
Recommended Applications
Skin care | Hair care | |
---|---|---|
Toner/Lotion | Serum | Shampoo |
Milky lotion | Face wash | Treatment |
Cream | Sun care | Conditioner |
Base makeup | Hair serum |
Collagen Metabolism
- ・Collagen is produced in the fibroblasts, which forms fibers to support the skin, after it is decomposed by enzymes and taken up by the fibroblast. This is called “collagen metabolism cycle”.
- ・HAbooster™ penetrates to the upper layer of the epidermis of the skin. By sending a signal from the epidermal cells to the fibroblasts, fibroblasts accelerate collagen production.
Collagen Production
HAbooster™ produces collagen in the skin.
Anti-aging Data
Activation of the collagen regeneration cycle also leads to the alleviation of nasolabial folds and crow’s feet.
Feel free to contact us for further information regarding our studies.
Hyalo-Oligo®“Penetrative” Hyaluronic acid
- ・Kewpie has been researching on nano-sized low molecular weight Hyaluronic acid from an early stage. As a result, Hyalo-Oligo® was developed as a functional Hyaluronic acid that has a higher moisturizing benefit than general Hyaluronic acid.
- ・It is a low molecular weight Hyaluronic acid with an average of less than 10,000 Da.
- ・It penetrates into the stratum corneum and moisturizes the skin from the inside.
Product information
INCI NAME | Hydrolyzed Hyaluronic Acid |
---|---|
IECIC2021 | 水解透明质酸 |
Function | Moisturizer |
Recommended dosage |
0.01%~ |
Appearance | Powder |
Average molecular weight |
Less than 10,000 Da |
ISO16128 | Natural Index:0 Derived Natural Index:1 |
Recommended Applications
Skin care | Hair care | |
---|---|---|
Toner/Lotion | Serum | Shampoo |
Milky lotion | Face wash | Treatment |
Cream | Sun care | Conditioner |
Base makeup | Cleanser | Hair serum |
Point makeup | Bath salts | Hair tonic/Scalp |
Penetration into the Stratum Corneum
As a result of a skin penetration test, we confirmed that Hyalo-Oligo® penetrated into the stratum corneum.
High moisture retentivity
It was confirmed that Hyalo-Oligo® has increased twice the amount of moisture in the skin than the general Hyaluronic acid.
Feel free to contact us for further information regarding our studies.
Hyalorepair®“Barrier Function Recovery” Hyaluronic acid
- ・Hyalorepair® is a Hyaluronic acid developed from the concept of repairing irritated rough skin and leading to smoother skin.
- ・Hyalorepair is a low molecular weight Hyaluronic acid that can have a barrier function with both hydrophobic and hydrophilic aspects for skin care.
- ・It improves the barrier function, repairs inflamed skin.
Product information
INCI NAME | C12-13 Alkyl Glyceryl Hydrolyzed Hyaluronate |
---|---|
Function | Moisturizer/Skin amelioration/ Barrier Function Recovery |
Recommended dosage |
0.05%~ |
Appearance | Powder |
Average molecular weight |
Less than 10,000 Da |
ISO16128 | Natural Index:0 Derived Natural Index:0.94~0.98 |
Recommended Applications
Skin care | Hair care | |
---|---|---|
Toner/Lotion | Serum | Shampoo |
Milky lotion | Face wash | Treatment |
Cream | Sun care | Conditioner |
Base makeup | Oil cleansing | Hair serum |
Lipstick | Point makeup |
Barrier Function Recovery
- ・The stratum corneum of the skin has a lamellar structure consisting of repeated aqueous and lipid layers.
- ・For healthy skin, the lamellar structure has a skin barrier function such as preventing the evaporation of moisture.
However, when the skin dries, the lamellar structure unbalances out and the barrier function does not work, so the evaporation of moisture increases and the skin becomes dry and sensitive. - ・Since Hyalo-repair® has a hydrophobic group and a hydrophilic group, this plays a role of connecting the aqueous layer and the lipid layer to give you a healthy lamellar structure.
- ・Hyalorepair® repairs the unbalanced lamellar structure, restoring the balance between lipid layers and aqueous layers (also known as the Barrier Function) and increases the moisturizing power of the skin.
Recovery of the barrier function
Hyalorepair® suppresses the water evaporation from the skin.
Improvement of damaged skin
The improvement of the skin condition was confirmed with a microscope.
Feel free to contact us for further information regarding our studies.
Hyaloveil®-P"Adhesive" Hyaluronic acid
- ・Hyaloveil®-P was developed based on the concept from the concern that general Hyaluronic acid is easily washed off when rinsing.
- ・By cationizing Hyaluronic acid, Hyaloveil®-P adsorbs to the hair and skin.
- ・In addition to moisturizing and viscoelasticity,Hyaloveil®-P is not easily washed off due to its adsorptive function.
- ・The “moisturizing veil” of Hyaluronic acid envelops the hair and skin and keeps it moisturized even after rinsing.
Product information
INCI NAME | Hydroxypropyltrimonium Hyaluronate |
---|---|
IECIC2021 | 羟丙基三甲基氯化铵透明质酸 |
Function | Moisturizer/Adsorption to skin, hair/Repairing damaged hair/ Anti-pollution |
Recommended dosage |
0.1%~ |
Appearance | Powder |
Average molecular weight |
500~800 kDa |
ISO16128 | Natural Index:0 Derived Natural Index:0.90~0.96 |
Recommended Applications
Skin care | Hair care | |
---|---|---|
Toner/Lotion | Serum | Shampoo |
Milky lotion | Face wash | Treatment |
Cream | Sun care | Conditioner |
Base makeup | Cleanser | Hair serum |
Bath salts |
Adsorption to the skin
- ・Since Hyaloveil®-P is charged positive, the adsorbing amount of “Hyaluronic acid” to the skin and hair increases.
- ・Hyaloveil®-P maintains moisture even after rinsing.
- ・By ionic bond, the amount of Hyaloveil®-P absorbed in the skin increases.
Cuticle Restoration
Lift-ups cuticles of hair are repaired by Hyaloveil®-P.
Feel free to contact us for further information regarding our studies.
Hyalo-Oligo® & Hyaloveil®-P
Effects of Air Pollution to the Skin
Air pollutants such as polluted particulates and gaseous substances in the air causes skin problems namely inflammation, oxidation, leading to skin aging.
Mechanism of Anti-Pollution
- ・Hyalo-Oligo® helps keep the skin in excellent condition by keeping the stratum corneum healthy and moisturized.
- ・Hyaloveil® has a positive charge blocking the air pollutants, not to penetrate into the skin.
Anti-pollution test ①
Inhibition of cell death
Hyalo-Oligo® × Hyaloveil®-P tends to inhibit cell death caused by air pollution.
<Test method>
- ・Skin sample human epidermis models EpiSkin®
- ・Hyaluronic acid sample Hyalo-Oligo® : Hyaloveil®-P (1 : 1) solution
- 1.Added DPE* and Hyalo-Oligo® ×Hyaloveil®-P solution to the human epidermis models EpiSkin® at the beginning of culture.
- 2.Added DPE 24h later once again.
- 3.After cultured 48h later, measured the rate of cell death using Alamar Blue.
Anti-pollution test ②
Inhibition of hyperkeratosis
Hyalo-Oligo® × Hyaloveil®-P tends to inhibit cell death caused by air pollution.
Anti-pollution test ③
Inhibition of oxidation
Hyalo-Oligo®×Hyaloveil®-P inhibits oxidation of the epidermis caused by air pollution.
Feel free to contact us for further information regarding our studies.