Functional
Hyaluronic Acid
for various benefits (Cosmetic Use)

Kewpie continues to
strive for research and
development using
Hyaluronic acid to
improve skin problems.

What is Functional Hyaluronic Acid ?

Our Functional Hyaluronic acids are not just ordinary humectants.
In addition to high water retention and moisturization which general Hyaluronic acid has, we add new functions through our unique technologies.
Our Functional Hyaluronic acids as an ingredient are scientifically proven with strong evidence to cater to your specific needs and use.
By blending our Functional Hyaluronic acids, it will lead you to healthy and vibrant skin.

HAbooster

Introduction Video

Functional Hyaluronic Acid

HAbooster"Promotes collagen cycle" Sodium hyaluronate

Very low molecular weight sodium hyaluronate promotes the collagen cycle and improves crow’s feet and nasolabial folds.Details >

Hyalorepair®“Barrier Function Recovery” Hyaluronic acid

Low molecular weight Hyaluronic acid which has been alkylated so that Hyarorepair® can have a barrier function recovery with both hydrophobic and hydrophilic aspects for skin care.Details >

Hyalo-Oligo®“Penetrative” Hyaluronic acid

Low molecular weight Hyaluronic acid not only covers the surface of the skin, but also penetrates and stays in the stratum corneum.Details >

Hyaloveil®-P"Adhesive" Hyaluronic acid

Relatively high molecular weight Sodium hyaluronate which has been cationized so that Hyaloveil®-P has an adhesive and coating effect for skin and hair.Details >

HAbooster"Promotes collagen cycle" Sodium hyaluronate

  • ・HAbooster is a Hyaluronic acid developed with the concept of promoting the collagen metabolism cycle which contributes to natural and beautiful skin.
  • ・HAbooster is a very low molecular weight Sodium hyaluronate with an average of 2,000 Da.
  • ・It penetrates to the upper layer of the epidermis of the skin and promotes on collagen metabolism to improve wrinkles and sagging.
HAbooster

Product information

INCI NAME Hydrolyzed Sodium Hyaluronate
IECIC2021 水解透明质酸钠
Function Moisturizer/Anti-wrinkle/
Elasticity
Recommended
dosage
0.1%~
Appearance Powder
Average molecular
weight
About 2,000 Da
ISO16128 Natural Index:0
Derived Natural Index:1

Recommended Applications

Skin care Hair care
Toner/Lotion Serum Shampoo
Milky lotion Face wash Treatment
Cream Sun care Conditioner
Base makeup Hair serum

Collagen Metabolism

  • ・Collagen is produced in the fibroblasts, which forms fibers to support the skin, after it is decomposed by enzymes and taken up by the fibroblast. This is called “collagen metabolism cycle”.
  • ・HAbooster™ penetrates to the upper layer of the epidermis of the skin. By sending a signal from the epidermal cells to the fibroblasts, fibroblasts accelerate collagen production.
Collagen Metabolism

Collagen production cycle

Collagen Production

HAbooster produces collagen in the skin.

Collagen Production

The effect of HAbooster™ on collagen (in vivo)

Anti-aging Data

Activation of the collagen regeneration cycle also leads to the alleviation of nasolabial folds and crow’s feet.

Anti-aging Data

Effects of HAbooster on nasolabial fold and crow's feet

Hyalo-Oligo®“Penetrative” Hyaluronic acid

  • ・Kewpie has been researching on nano-sized low molecular weight Hyaluronic acid from an early stage. As a result, Hyalo-Oligo® was developed as a functional Hyaluronic acid that has a higher moisturizing benefit than general Hyaluronic acid.
  • ・It is a low molecular weight Hyaluronic acid with an average of less than 10,000 Da.
  • ・It penetrates into the stratum corneum and moisturizes the skin from the inside.
Hyalo-Oligo

Product information

INCI NAME Hydrolyzed Hyaluronic Acid
IECIC2021 水解透明质酸
Function Moisturizer
Recommended
dosage
0.01%~
Appearance Powder
Average molecular
weight
Less than 10,000 Da
ISO16128 Natural Index:0
Derived Natural Index:1

Recommended Applications

Skin care Hair care
Toner/Lotion Serum Shampoo
Milky lotion Face wash Treatment
Cream Sun care Conditioner
Base makeup Cleanser Hair serum
Point makeup Bath salts Hair tonic/Scalp

Penetration into the Stratum Corneum

As a result of a skin penetration test, we confirmed that Hyalo-Oligo® penetrated into the stratum corneum.

Penetration into the Stratum Corneum

Unique fluorescence

Structure of the skin

Structure of the skin (hematoxylin/eosin dye)
* Research institute commissioned testing : BIO alternatives

High moisture retentivity

It was confirmed that Hyalo-Oligo® has increased twice the amount of moisture in the skin than the general Hyaluronic acid.

High moisture retentivity

Skin moisture increase

Hyalorepair®“Barrier Function Recovery” Hyaluronic acid

  • ・Hyalorepair® is a Hyaluronic acid developed from the concept of repairing irritated rough skin and leading to smoother skin.
  • ・Hyalorepair is a low molecular weight Hyaluronic acid that can have a barrier function with both hydrophobic and hydrophilic aspects for skin care.
  • ・It improves the barrier function, repairs inflamed skin.
Hyalorepair

Product information

INCI NAME C12-13 Alkyl Glyceryl
Hydrolyzed Hyaluronate
Function Moisturizer/Skin amelioration/
Barrier Function Recovery
Recommended
dosage
0.05%~
Appearance Powder
Average molecular
weight
Less than 10,000 Da
ISO16128 Natural Index:0
Derived Natural Index:0.94~0.98

Recommended Applications

Skin care Hair care
Toner/Lotion Serum Shampoo
Milky lotion Face wash Treatment
Cream Sun care Conditioner
Base makeup Oil cleansing Hair serum
Lipstick Point makeup

Barrier Function Recovery

  • ・The stratum corneum of the skin has a lamellar structure consisting of repeated aqueous and lipid layers.
  • ・For healthy skin, the lamellar structure has a skin barrier function such as preventing the evaporation of moisture.
    However, when the skin dries, the lamellar structure unbalances out and the barrier function does not work, so the evaporation of moisture increases and the skin becomes dry and sensitive.
  • ・Since Hyalo-repair® has a hydrophobic group and a hydrophilic group, this plays a role of connecting the aqueous layer and the lipid layer to give you a healthy lamellar structure.
  • ・Hyalorepair® repairs the unbalanced lamellar structure, restoring the balance between lipid layers and aqueous layers (also known as the Barrier Function) and increases the moisturizing power of the skin.
Barrier Function Recovery

Approach to Barrier Function Recovery mechanism
(including hypothesis)

Recovery of the barrier function

Hyalorepair® suppresses the water evaporation from the skin.

Recovery of the barrier function

Change rate of transepidermal water loss 3 days later

Improvement of damaged skin

The improvement of the skin condition was confirmed with a microscope.

Improvement of damaged skin

Improvement of damaged skin

<Test method> After damage the forearm skin with mixed solution of acetone and ether.
Apply the samples everyday to the damaged skin before bedtime for 5 days.

Hyaloveil®-P"Adhesive" Hyaluronic acid

  • ・Hyaloveil®-P was developed based on the concept from the concern that general Hyaluronic acid is easily washed off when rinsing.
  • ・By cationizing Hyaluronic acid, Hyaloveil®-P adsorbs to the hair and skin.
  • ・In addition to moisturizing and viscoelasticity,Hyaloveil®-P is not easily washed off due to its adsorptive function.
  • ・The “moisturizing veil” of Hyaluronic acid envelops the hair and skin and keeps it moisturized even after rinsing.
Hyaloveil

Product information

INCI NAME Hydroxypropyltrimonium
Hyaluronate
IECIC2021 羟丙基三甲基氯化铵透明质酸
Function Moisturizer/Adsorption to skin,
hair/Repairing damaged hair/
Anti-pollution
Recommended
dosage
0.1%~
Appearance Powder
Average molecular
weight
500~800 kDa
ISO16128 Natural Index:0
Derived Natural Index:0.90~0.96

Recommended Applications

Skin care Hair care
Toner/Lotion Serum Shampoo
Milky lotion Face wash Treatment
Cream Sun care Conditioner
Base makeup Cleanser Hair serum
Bath salts

Adsorption to the skin

  • ・Since Hyaloveil®-P is charged positive, the adsorbing amount of “Hyaluronic acid” to the skin and hair increases.
  • ・Hyaloveil®-P maintains moisture even after rinsing.
  • ・By ionic bond, the amount of Hyaloveil®-P absorbed in the skin increases.
Adsorption to the skin

Residue on the skin

Cuticle Restoration

Lift-ups cuticles of hair are repaired by Hyaloveil®-P.

Cuticle Restoration

Effects on the lift-ups of cuticles of hair

Common skin care issues in modern days

Hyalo-Oligo® & Hyaloveil®-P

Effects of Air Pollution to the Skin

Air pollutants such as polluted particulates and gaseous substances in the air causes skin problems namely inflammation, oxidation, leading to skin aging.

Mechanism of Anti-Pollution

  • ・Hyalo-Oligo® helps keep the skin in excellent condition by keeping the stratum corneum healthy and moisturized.
  • ・Hyaloveil® has a positive charge blocking the air pollutants, not to penetrate into the skin.
Mechanism of Anti-Pollution

Anti-pollution test ①
Inhibition of cell death

Hyalo-Oligo® × Hyaloveil®-P tends to inhibit cell death caused by air pollution.

<Test method>

  • ・Skin sample human epidermis models EpiSkin®
  • ・Hyaluronic acid sample Hyalo-Oligo® : Hyaloveil®-P (1 : 1) solution
    • 1.Added DPE* and Hyalo-Oligo® ×Hyaloveil®-P solution to the human epidermis models EpiSkin® at the beginning of culture.
    • 2.Added DPE 24h later once again.
    • 3.After cultured 48h later, measured the rate of cell death using Alamar Blue.
Inhibition of cell death

Inhibition of cell death

※DPE・・・Diesel Particulate Extract
※PBS・・・Phosphate Buffered Saline

Anti-pollution test ②
Inhibition of hyperkeratosis

Hyalo-Oligo® × Hyaloveil®-P tends to inhibit cell death caused by air pollution.

If hyperkeratosis occurs, the skin becomes stiff and the skin texture gets rough.

Inhibition of hyperkeratosis

※If hyperkeratosis occurs, the skin becomes stiff and the skin texture gets rough.

<Test method>
We made frozen section of the human epidermis models EpiSkin® used for inhibitory test of cell death, and conducted hematoxylin and eosin stain.

Anti-pollution test ③
Inhibition of oxidation

Hyalo-Oligo®×Hyaloveil®-P inhibits oxidation of the epidermis caused by air pollution.

If hyperkeratosis occurs, the skin becomes stiff and the skin texture gets rough.

Inhibition of oxdation

<Test method>
We detected the immunostained carbonylated protein by using the frozen section of the 3D skin models EpiSkin® to find cell death inhibition.

Kewpie has several types of Functional Hyaluronic acids which will contribute to your development for cosmetics.

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We are always by your side

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