Hyabest®(S)LF-P
Clinically Proven Inner Beauty*Hyaluronic Acid
(as Sodium Hyaluronate)
*Skin hydration
What is Hyaluronic acid?
- ・Isolated from the vitreous of bovine eyes in 1934.
- ・A type of mucopolysaccharide composed of glucuronic acid and N-acetylglucosamine with maximum molecular weight of up to 7,000,000 Dalton.
- ・Retain high moisture, elasticity, biological compatibility.
- ・Distributed in the human body such as skin, synovial fluid and in the eyes (vitreous body).
- ・High concentration of Hyaluronic acid exists in the inner layer of the skin (epidermis/dermis).
- ・Acts to hydrate and lubricate within the skin.
Skin
Epidermis
Dermis
Dermis
Dermis won't
retain moisture
leading to dry skin!
- ・Hyaluronic acid and collagen are important substances for maintaining healthy skin.
- ・Hyaluronic acid decreases as we age. Oral intake of Hyaluronic acid helps to replenish the lost Hyaluronic acid.
The decrease in amount of
Hyaluronic acid and collagen with age
![The decrease in amount of Hyaluronic acid and collagen with age](/en/assets/img/project/finechemical/hyaluronic/hyabest-lf-p/img02.jpg)
Longas MO.et al.: Evidence for the structural changes in dermatan sulfate and Hyaluronic acid with aging. Referring the data from ”Cargo-hydr.Res1987;159:127~136”, “Shuster et al.Br J Dermatol.1975.93.639”
The Mechanism of Hyaluronic acid
- ・Oral ingestion of Hyaluronic acid is not decomposed in the small intestine by digestive enzymes.
- ・Decomposed and absorbed by the intestinal bacteria in the large intestine into Oligo Hyaluronic acid.
- ・Oligo hyaluronic acid is absorbed into the host body and transferred into the skin through blood.
- ・Leads to activating the collagen metabolism and fibroblast to promote the production of Hyaluronic acid.
![Mechanism of Hyaluronic acid](/en/assets/img/project/finechemical/hyaluronic/hyabest-lf-p/img03_pc.png)
Clinically Proven Evidence
Skin hydration
With intake of Hyabest(S)LF-P, skin dryness and condition has improved.
Improvement of dry skin after oral intake
*significant difference compared with group of placebo P<0.05
Testee:Japanese females
N=42, age 35-60
< Ingestion of hyaluronans (molecular weights 800 k and 300 k) improves dry skin conditions: a randomized, double blind, controlles study.J.Clin. Biochem. Nutr. 2015 >
Kewpie has published international papers with various evidences. Please inquire us for further studies.
What is Hyabest®(S)LF-P
Product Name | Characteristics | Average molecular weight (range)※1 |
Shelf life (condition)※2 |
---|---|---|---|
Hyabest(S)LF-P | Highly-pure Sodium Hyaluronate for dietary supplements. Skin hydration by oral administration has been clinically proven(published). | 200k~500k |
1080 days (15℃~25℃) |
※1:It is not the specification item of the products. ※2:Shelf life is based on the unopened condition after the production.
- ・Bio-fermentation.
- ・GMO Free.
- ・U.S. FSMA compatible.
- ・Canada NNHPD registered.
- ・Corresponding to Japan’s Foods with Function Claims. ※Notification:It has been reported that Sodium Hyaluronate helps retain moisture in the skin and leads to the alleviation of dryness.
- ・Hyabest Logo (Trademark) :Can be used after concluding an Agreement. ※Conditions need to be confirmed individually.
Fine Chemical Inquiries
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About Kewpie
Kewpie Corporation Fine Chemical Division
- ・Kewpie is a Japanese food manufacture producing mayonnaise founded in 1919.
- ・At Fine Chemicals Division, Kewpie extracts and refines various active ingredients for foods, cosmetics and pharmaceuticals.
We utilize the egg functionality and vinegar fermentation technology through the production of mayonnaise. - ・Kewpie’s ongoing research into Hyaluronic acid for over 30 years.